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How does the endocannabinoid system work?
Sep. 15, 2023 by SOMAÍ Pharmaceuticals
How does the endocannabinoid system work?
The ECS is made up of three core components:
1 Endocannabinoids, also referred to as endogenous cannabinoids, that are molecules made by your body
2
Cannabinoid
receptors
3
Enzymes that synthesise
and degrade
endocannabinoids
1 Endocannabinoids
Endocannabinoids are chemical messengers that bind to cannabinoid receptors to signal that the ECS needs to take action. They are similar to cannabinoids, except that they are produced by your body.
There are two key endocannabinoids that have been identified:
- Anandamide (AEA)
- 2-arachidonoyglyerol (2-AG)
These chemical messengers keep internal functions running smoothly and are produced by your body as and when they are needed.
2 Cannabinoid receptors
Cannabinoid receptors can be found throughout your body. To-date, two cannabinoid receptors that have been studied: CB1 and CB2. CB1 receptors can be found in abundance in the central and peripheral nervous system, as well as the gastrointestinal tract and skeletal system. CB2 receptors, on the other hand, are mostly located in the peripheral nervous system, particularly immune cells. Endocannabinoids can bind to either receptor. The influence that this has depends on where the receptor is located, and which endocannabinoid binds to it.
CB1 receptors influence pain, sleep, appetite, and memory, and mediate most psychoactive effects of cannabinoids. On the other hand, CB2 receptors are primarily involved in anti-inflammatory and immunosuppressive actions.
3 Enzymes
Enzymes are responsible for synthesising and breaking down endocannabinoids once they have carried out their function.
There are two main enzymes that are responsible for the degradation of endocannabinoids:
- Fatty acid amid hydrolase, which breaks down endocannabinoid AEA
- Monoacylglycerol lipase, which typically breaks down 2-AG
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Michael Sassano & Antonio Guedelha: GMP Article 10: Production Cost Calculation Systems in GMP
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MGC Pharma, Cansativa Group & Somai Pharmaceuticals announced among Cannabis Europa sponsors
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The European Cannabis Report: 7th Edition | Expert Opinions: Michael Sassano (page 34)
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3 Reasons Cannabis Sin Stocks Stay Strong in Volatile Markets
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Inflation: is it affecting the cannabis market?
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The case for improving absorption for cannabinoids using ethosomes
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Opinion: 2022 could be the year for pharmaceutical marijuana
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SOMAÍ Pharmaceuticals + Huge Gage Cannabis News!
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Karma Koala Podcast Episode 67: This Week Michael Sassano, Inesa Ponomariovaite & Our Regular Segment From Dentons German Cannabis Head, Peter Homberg
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Innovations in Dosing Technologies: Getting an Accurate Hit, Every Time
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Safety and Culture at Forefront of Cannabis Social Club vs. Dispensary Debate
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Synthetic Cannabinoids versus Plant-Derived Products
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Spotlight Interview with Michael Sassano, CEO and Chairman of the Board for Somai Pharmaceuticals
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How Germany Can Enter The Adult-Use Cannabis Market Successfully
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How Germany Can Enter The Adult-Use Cannabis Market Successfully
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Portugal Is Highly Likely To Legalize Recreational Cannabis
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Michael Sassano – Somai Pharmaceuticals – Conforming to the Highest Pharmaceutical Standards
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Uber Eats to Offer “Baked Goods” with Canadian Cannabis Partnership
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Croptober – Navigating the Business of Cannabis Cultivation and Sustainability – Michael Sassano
YouTube - Somai Pharmaceuticals On Thursday, October 28 Excelsior College hosted a cannabis webinar, Croptober: Navigating the Business of Cannabis...
Cannabis Europa London 2021 – Michael Sassano
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Which Countries Will Likely Legalize Cannabis In 2022 And Why Isn’t The US Among Them?
Benzinga Cannabis reform is heating up across the nation. With it comes a booming multinational market, including a projected $102...
Michael Sassano, Renowned Pharmaceutical Expert, and Founder and CEO of Somai Pharmaceuticals LTD Zoom Interviewed
EIN Presswire Michael Sassano, Renowned Pharmaceutical Expert, Founder & CEO of Somai Pharmaceuticals LTD Zoom Interviewed for The DotCom Magazine
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How SOMAÍ is Bringing ‘Peak Efficiency’ and ‘Peak Profitability’ to the European Cannabis Market
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Cannabis Investment: 7 Best Marijuana Stocks to Buy for 2022
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Michael Sassano: GMP Series #8: Manufacturing Startup
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Few Medical Cannabis Licenses in Portugal Have Been Awarded
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Cannabis Co. Receives $3M ‘Innovative Products’ Grant From Government, EU In Portugal
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SOMAÍ Pharmaceuticals awarded €2.7M in funding from Portugal 2020 Grant
BusinessCann SOMAÍ Pharmaceuticals Unipessoal LDA has received an innovative products grant of 2.7 million euros by the Portugal 2020 committee....
Projeto Nº POCI-02-0853-FEDER-179647
SOMAÍ Pharmaceuticals Unipessoal LDA has officially opened its new state-of-the-art pharmaceutical EU-GMP facility in Portugal.
EU: Cannabis company receives €2.7 million grant
MMJ Daily Somaí Pharmaceuticals has received a €2.7 million grant from the Portugal 2020 committee.
SOMAÍ Pharmaceuticals Erhält Im Rahmen Von Portugal 2020 Fördermittel In Höhe Von 2,7 Mio. Euro
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Finanz Nachrichten LISSABON, Portugal, Nov. 10, 2021 (GLOBE NEWSWIRE) -- SOMAÍ Pharmaceuticals Unipessoal LDA hat vom Portugal 2020-Komitee Fördermittel für...
SOMAÍ Pharmaceuticals awarded €2.7M in funding from Portugal 2020 Grant
Yahoo Finance LISBON, Portugal, Nov. 10, 2021 (GLOBE NEWSWIRE) -- SOMAÍ Pharmaceuticals Unipessoal LDA has received an innovative products grant...
SOMAÍ Pharmaceuticals awarded €2.7M in funding from Portugal 2020 Grant
AP News LISBON, Portugal, Nov. 10, 2021 (GLOBE NEWSWIRE) -- SOMAÍ Pharmaceuticals Unipessoal LDA has received an innovative products grant...
SOMAÍ Pharmaceuticals awarded €2.7M in funding from Portugal 2020 Grant
Opera News LISBON, Portugal, Nov. 10, 2021 (GLOBE NEWSWIRE) -- SOMAÍ Pharmaceuticals Unipessoal LDA has received an innovative products grant...
SOMAÍ Pharmaceuticals awarded €2.7M in funding from Portugal 2020 Grant
Profiles in Legalization LISBON, Portugal — SOMAÍ Pharmaceuticals Unipessoal LDA has received an innovative products grant of 2.7 million euros...
SOMAÍ Pharmaceuticals bénéficie d’un financement de 2,7 millions d’euros de Portugal 2020
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These Are The Cannabis Industry’s Biggest Tricks and Treats So Far
Benzinga Halloween is almost here. As costumed revelers prepare for a weekend of celebrations, the cannabis industry readies for the...
Michael Sassano: GMP Series #7: Personnel Recruitment
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Michael Sassano: GMP Series Part 6 – Quality Assurance Implementation
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Why Germany is Not the Future Leader of European Cannabis
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Michael Sassano CEO and Chairman Somai Pharmaceuticals: GMP Series #5: ERP Implementations
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The Advantages of Ethanol Extraction
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Does Big Business Provide A Better Look Into Cannabis Reform Than Capitol Hill?
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Does Big Business Provide A Better Look Into Cannabis Reform Than Capitol Hill?
The Fresh Toast Operators in various sectors of cannabis feel that the industry provides a better insight into regulatory needs...
Does Big Business Provide A Better Look Into Cannabis Reform Than Capitol Hill? Operators Believe So.
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Cannabis Stocks Next Big Wave Is Coming Late August
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Michael Sassano and Antonio Guedelha: GMP Series Part 4: Laboratory Set-Up
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GMP Series Part 3: Process Equipment Procurement
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Could Drug Store Giants Eventually Sell THC? It’s Possible, But Many Hurdles Remain
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European Cannabis is Starting to Look Like the US Market 10 Years Ago
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CANNA WORLD EXPO EUROPEAN UPDATE SOMAI PHARMACEUTICALS CEO MICHAEL SASSANO
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Beyond CBD, THC: ‘Minor’ Cannabinoids Flood Market — Lack of data is concerning, even for practitioners who believe in medical cannabis
MedPage Today On the heels of the cannabidiol (CBD) craze come three other cannabinoids touted as potential treatments for various...
Why GMP is the Future of Quality Control for the Global Industry
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SOMAÍ Pharmaceuticals Bringing The Future Of European Cannabis Market
Benzinga When the COVID-19 pandemic hit the world by surprise last year, cannabis businesses around the world faced the uncertainty...
SOMAÍ Pharmaceuticals Bringing The Future Of European Cannabis Market
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Morocco: Cannabis Legislation but the Devil in the Details
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Low-Cost Pot Stocks To Consider, According To SOMAÍ Pharmaceuticals CEO Mike Sassano
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Cannabis Revival and Year of the SPAC’s: What’s To Be Expected the Rest of 2021?
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SPAC Mania: The Biggest Cannabis Boom Is Yet To Come
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GMP Series Part 2: Building and Design – Authored By: Michael Sassano and Antonio Guedelha
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Benzinga Cannabis Capital Conference | February 25-26, 2021 | Michael Sassano
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Cannabiz: How to Invest in This Growing Industry
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GMP & Compliance: GMP SERIES #1: “Starting Your GMP Approval Process for Cannabis Correctly”
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PREDICTIONS | Want to know the future? There are two ways: a crystal ball or really smart people (pages 74-75)
B2B Wholesaler Magazine Mike Sassano, CEO and Chairman of Somai Pharmaceutical: “2021 is shaping up to be the most explosive...
Ingenious Cannabis Entrepreneurs to watch in 2021
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These Are The Top European Cannabis Companies
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9 Things to Consider When Raising Capital for Startups in Europe
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Tantalizing Terpenes Boost Cannabinoid Blends For The European Market (pages 20-21)
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UK to see largest medical cannabis market growth in Europe 2020 to 2025
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Desert Oasis | Solaris Farms is capitalizing on a prime location and plenty of Nevada sunshine (page 58-61 November issue)
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Cannabis Top 20: North America’s Largest Commercial Grows
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Real Deals – Michael Sassano
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Best practices for securing your cannabis grow operations and supply chains
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Cannabis Terpenes: What Growers Need to Know
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Opening the Pot: Vegas Cannabis Industry Moving Ahead Amidst COVID
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California joins push to let cannabis businesses use banks as part of coronavirus relief
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Cannabis company executives speak to the industry’s trying times
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Why Large-scale cannabis producers are turning to Hybrid Greenhouses
Joomag "The environment can be controlled in both indoor and hybrid greenhouses in almost the exact same way, but it...
Lawmakers Look to Include Cannabis Banking Reform in Next COVID-19 Stimulus Bill
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COVID-19 Is Leaving Its Mark On The Cannabis Industry, Insiders Say
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Why Cannabis Will Boom During the “New Normal”
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Cannabis Do-Gooders: These Companies Are Lending A Helping Hand Against COVID-19
Benzinga “Creating a safe environment while cannabis is deemed 'essential' added tremendous positive energy for our team, while at the...
Cannabis Do-Gooders: These Companies Are Lending A Helping Hand Against COVID-19
Yahoo finance "Recently, in-order to give back to the community and create outward good will, Solaris Farms reduced pricing to...
Hemp Companies Step Up To Help During Pandemic
Hemp Market Report “Although our first priority is to the safety of our employees and doing our part to slow...
Cannabis Pros Sound Off On How Coronavirus Pandemic Will Affect Industry
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CannaBusiness Tips For Coronavirus Times
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Cannabis Executives on Turbulent Markets: “Don’t Panic”
Equities “I’m a believer in letting the flood gates open. But I see things from a well established position. The...
Michael Sassano: the man bringing US cannabis know-how to Europe
Cleanroom Technology The focus of the marketplace is on CBD, Sassano admits, noting regulation is developing. "Places like Switzerland have...
Michael Sassano: the man bringing US cannabis know-how to Europe
NBR A US native, Sassano believes a more liberal approach to the use of cannabis will take some time for...
Michael Sassano: the man bringing US cannabis know-how to Europe
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New Cannabis Products: Kiva’s Camino CBN Line, Solaris x Cannabis & Culture’s Line And A Topical Cream
Yahoo finance "With over $100,000 in sales the first week of launch, it’s clear that Culture and Cannabis’s reach means...
New Cannabis Products: Kiva’s Camino CBN Line, Solaris x Cannabis & Culture’s Line And A Topical Cream
Benzinga Michael Sassano, CEO of Solaris, told Benzinga, "The merger of the Culture and Cannabis media group with Solaris Farms...
European Union Urges Member Nations to Vote for World Health Organization’s Cannabis Rescheduling Recommendations
Cannabis Business Times “The 1961 Narcotics Act of Europe is similar to [the Drug Enforcement Administration’s (DEA)] Schedule I in...
“Marijuana is a global trend that can no longer be stopped.”
Incrussia The largest marijuana market in Europe is now Germany ($100 million). The American market is estimated at about $10...
Which European Countries Cannabis Investors Should Watch in the New Decade
Equities Europe is at the crawling stage of cannabis development and starting their first awkward steps with medical acceptance. -...
Solaris Farms & Tech-Driven Growing
Culture & Cannabis The cultivation is relatively new, springing up in the summer of 2016. Despite its age, Solaris Farms...
‘Big Cannabis’ Technologically Ahead Of Its Times, But Post-Harvest Automation Remains Elusive
Forbes “The tech is getting closer but we’re not there yet,” said Michael Sassano, CEO, Solaris Farms, a cannabis cultivator...
U.S. leads in cannabis innovation, but cedes global market to Canada
The Denver Post The genetics and sophistication underlying the U.S. cannabis industry lead to better-quality and higher-potency flowers for those...
American pot is the gold standard. But Canada leads the export game — for now
Salon The genetics and sophistication underlying the U.S. cannabis industry lead to better-quality and higher-potency flowers for those who smoke...
American pot is the gold standard. But Canada leads the export game — for now
Kaiser Health “The world wants that technology,” said Michael Sassano, CEO of Solaris Farms, the largest cannabis hybrid greenhouse in...
From Seed to Sale Nevada’s Cash Crop Cannabis Industry
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America’s marijuana growers are the best in the world, but federal laws are keeping them out of global markets
Washington Post Federal prohibitions are getting in the way of efforts to grow the U.S. marijuana business into a global...
What Should Investors Take Away From MJBizCon 2019?
Equities Marijuana Business Daily’s annual MJBizCon is the largest conference and convention in the global legal cannabis industry. This year's...
How to Do Cannabis Cultivation Business Planning for Growth
B-Plans Developing a cannabis cultivation business requires significant planning, dedication, and focus. Initially, you’ll need to develop a solid plan...
“5 Things I Wish Someone Told Me Before I Started Leading a Cannabis Business”, with Michael Sassano and Len Giancola
Medium The cannabis business is a complete dedication and you must make large sacrifices for it. It is very fast...
Key trends when investing in the Cannabis industry in Opportunity Zones
Opportunity Zone Cannabis land development is growing and gaining traction in Opportunity Zones (OZ). Not only has a large amount...
Vegas Hybrid GreenHouse Dominance by Mike Sassano – page 20
Vegas Cannabis magazine
The Cannabis Cultivation Costs by State
MG Retail Magazine To the outside world, the legal cannabis industry appears to be one big cash machine. While it’s...
Mike Sassano: Increasing Potency with Greenhouse Technology
Ganjapreneur Michael Sassano is the CEO and founder of Solaris Farms, one of three large greenhouse cannabis cultivators in Nevada....
OZ WRITERS COUNCIL DIRECTORY
OZ WRITERS COUNCIL DIRECTORY The Council is an invitation-only group of executives and professionals with experience in the Opportunity Zone...
Are cannabis hand-trimmers an endangered species?
Leafly Many people in the cannabis industry start out as trimmers. Wearing “sticky gloves” is a way to learn the...
Automation and sensors in hybrid greenhouses
AgTechTomorrow Solaris is a high tech hybrid greenhouse designed specifically for desert environments. It was the first ground up hybrid...
Desert Greenhouse Cultivation
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Five Diverse Questions With Michael Sassano, Founder: Solaris Farms
Forbes I was born and raised in Cleveland, Ohio before attending Boston University. I graduated Cum Laude with Distinction in...
Automation is the Future of Cannabis
Equities As industries evolve, the companies within them consistently work to implement new methods that update their processes so they...
How Solaris Farms’ Michael Sassano Works: Cannabis Workspace
Cannabis Business Times In this installment, CBT presents an up-close look at the tools and habits behind the Nevada-based cultivator’s...
Federal Court Orders DEA to Explain Inaction on Cannabis Cultivation Applications
Analytical Cannabis Michael Sassano, founder and CEO of the Nevada-based cannabis cultivation operation Solaris Farms, told the Cannabis Business Times,...
Federal Court Orders DEA to Explain Why It Has Ignored Cannabis Cultivation Applications
Cannabis Business Times A federal court has ordered the Drug Enforcement Administration (DEA) to explain why it has not responded...
Soma Pharmaceuticals Reveals Plans for Ireland’s Medical Cannabis Market
Cannabis Business Times As cannabis policy reform continues to sweep the globe, Ireland has launched a medical cannabis pilot program,...
What Technology Will Most Impact The Cannabis Industry? 24 Experts Share Their Insights
Disruptor Daily Cannabis legalization is gaining serious steam, and the industry is coming to a crossroads as nationwide demand for...
Solaris Farms Tackles Desert Heat with Global Tech
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What Trends Are Shaping The Cannabis Industry In 2019? 25 Experts Weigh In
Disruptor Daily Considering the topic of this article, you'd be forgiven for wondering whether it's 4/20 yet. It's not, but...
What’s The Future Of The Cannabis Industry? 28 Experts Share Their Perspectives
Disruptor Daily Bob Dylan once said that the times are a-changin', and no industry echoes that message like the cannabis...
CANNABIS INTERVIEW – MICHAEL SASSANO – FOUNDER SOLARIS FARMS
Cannabis Magazine Want to know more about one of the world’s largest greenhouses for growing cannabis? We sat down with...
Mike Sassano – A Cannabis Business in the Opportunity Zone
BuzzSprouts Mike Sassano's eclectic career has taken him from Cleveland to Wall Street, to Monaco and now Las Vegas. As...
Define “Organic”: The Cannabis Movement Is Stuck On Labeling
Dope Magazine Michael Sassano of Nevada’s Green Cross of America said all cannabis grown in the state is done without...